Management of Genital Herpes Simplex Infection

Challenges in genital herpes simplex virus management.

Development of serologic assays to detect antibodies to herpes simplex virus (HSV) glycoproteins (g)G1 and (g)G2 has allowed accurate definition of the seroprevalence of HSV-2 worldwide. Studies from all continents indicate epidemic proportions of HSV-2 infection. In the United States, 1 in 5 sexually active adults is infected. In Africa and the Caribbean, HSV prevalence is higher. Since the de...

Swiss recommendations for the management of genital herpes and herpes simplex virus infection of the neonate.

Genital herpes is being recognised as a medical problem of increasing importance. Diagnosis and management are complex. The present recommendations have been established by a multidisciplinary panel of specialists and endorsed by all Swiss medical societies involved in the medical care of such patients. The aim is to improve the care of affected patients, to reduce horizontal and vertical trans...

Valacyclovir to reduce transmission of genital herpes simplex virus infection.

fallacy. Am J Epidemiol 1988; 127:893–904. 3. Greenland S, Robins J. Invited commentary: ecologic studies–biases, misconceptions, and counterexamples. Am J Epidemiol 1994; 139: 747–60. 4. Blaser MJ, Chen Y, Reibman J. Does Helicobacter pylori protect against asthma and allergy? Gut 2008; 57:561–7. 5. Höök-Nikanne J, Pérez-Pérez GI, Blaser MJ. Antigenic characterization of Helicobacter pylori st...

DNA immunization against experimental genital herpes simplex virus infection.

A nucleic acid vaccine, expressing the gene encoding herpes simplex virus (HSV) type 2 glycoprotein D (gD2) under control of the cytomegalovirus immediate-early gene promoter, was used to immunize guinea pigs against genital HSV-2 infection. The vaccine elicited humoral immune responses comparable to those seen after HSV-2 infection. Immunized animals exhibited protection from primary genital H...

Primary genital herpes simplex infection associated with Jewish ritual circumcision.